• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >A prospective, randomized trial of early enteral feeding after resection of upper gastrointestinal malignancy.
【2h】

A prospective, randomized trial of early enteral feeding after resection of upper gastrointestinal malignancy.

机译：一项上消化道恶性肿瘤切除术后早期肠内喂养的前瞻性随机试验。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The purpose of the study was to determine whether early postoperative enteral feeding with an immune-enhancing formula (IEF) decreases morbidity, mortality, and length of hospital stay in patients with upper gastrointestinal (GI) cancer. SUMMARY BACKGROUND DATA: Early enteral feeding with an IEF has been associated with improved outcome in trauma and critical care patients. Evaluable data documenting reduced complications after major upper GI surgery for malignancy with early enteral feeding are limited. METHODS: Between March 1994 and August 1996, 195 patients with a preoperative diagnosis of esophageal (n = 23), gastric (n = 75), peripancreatic (n = 86), or bile duct (n = 11) cancer underwent resection and were randomized to IEF via jejunostomy tube or control (CNTL). Tube feedings were supplemented with arginine, RNA, and omega-3 fatty acids, begun on postoperative 1, and advanced to a goal of 25 kcal/kg per day. The CNTL involved intravenous crystalloid solutions. Statistical analysis was by t test, chi square, or logistic regression. RESULTS: Patient demographics, nutritional status, and operative factors were similar between the groups. Caloric intake was 61% and 22% of goal for the IEF and CNTL groups, respectively. The IEF group received significantly more protein, carbohydrate, lipids and immune-enhancing nutrients than did the CNTL group. There were no significant differences in the number of minor, major, or infectious wound complications between the groups. There was one bowel necrosis associated with IEF requiring reoperation. Hospital mortality was 2.5% and median length of hospital stay was 11 days, which was not different between the groups. CONCLUSION: Early enteral feeding with an IEF was not beneficial and should not be used in a routine fashion after surgery for upper GI malignancies.
机译：目的：本研究的目的是确定术后早期采用免疫增强剂（IEF）进行肠内喂养是否可以降低上消化道（GI）癌症患者的发病率，死亡率和住院时间。摘要背景数据：早期用IEF进行肠内喂养与创伤和重症监护患者的预后改善有关。大型肠胃大手术后早期肠内喂养导致恶性肿瘤并发症的减少的可评价数据有限。方法：在1994年3月至1996年8月之间，对195例术前诊断为食道癌（n = 23），胃癌（n = 75），胰周癌（n = 86）或胆管癌（n = 11）的患者进行了手术切除，通过空肠造口管或对照（CNTL）随机分配至IEF。试管饲喂补充有精氨酸，RNA和omega-3脂肪酸，从术后1开始就开始摄取，并提高到每天25 kcal / kg的目标。 CNTL涉及静脉内晶体溶液。通过t检验，卡方或logistic回归进行统计分析。结果：两组患者的人口统计学，营养状况和手术因素相似。 IEF和CNTL组的卡路里摄入量分别是目标的61％和22％。与CNTL组相比，IEF组接受的蛋白质，碳水化合物，脂质和免疫增强营养素明显更多。两组之间的轻度，重度或传染性伤口并发症的数量没有显着差异。与IEF相关的肠坏死需要再次手术。住院死亡率为2.5％，中位住院时间为11天，两组之间无差异。结论：早期用IEF肠内喂养对上消化道恶性肿瘤无益，且不应在术后常规使用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号